By Andrew Franklin
During the process the immune reaction, antigen-activated B cells produce antibodies with elevated affinity for the antigen, a procedure referred to as affinity maturation. a number produces antibodies with successively larger affinities with repeated publicity to an identical antigen, that's the main wherein so much vaccines work.
Affinity maturation is dependent upon hypermutation, an iterative means of mutation at antibody-encoding genes, by way of confident choice of B cells expressing antibodies with elevated affinity. The mechanism of hypermutation is taken into account to be one of many final nice mysteries in molecular biology. Mutation can result in genomic instability, so how are mutations selectively brought to antibody-encoding genes in activated B cells?
A significant leap forward got here in 2000 with the invention that activation-induced deaminase (AID) is actually required for hypermutation. This used to be in 2002 via facts that relief without delay edits the DNA that encodes an antibody in an activated B mobile. a lot has on account that been learnt in regards to the biochemistry and law of reduction, however the mechanism wherein it truly is recruited in particular to antibody-encoding genes continues to be enigmatic. knowing this recruitment is clinically major simply because off-target reduction job at oncogenes may end up in chromosomal translocations and tumorigenesis.
This e-book summarizes the examine on relief within the context of its relevant position within the affinity maturation of B cells.
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Extra resources for Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci
Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci by Andrew Franklin