By Andrew Franklin

During the process the immune reaction, antigen-activated B cells produce antibodies with elevated affinity for the antigen, a procedure referred to as affinity maturation. a number produces antibodies with successively larger affinities with repeated publicity to an identical antigen, that's the main wherein so much vaccines work.
Affinity maturation is dependent upon hypermutation, an iterative means of mutation at antibody-encoding genes, by way of confident choice of B cells expressing antibodies with elevated affinity. The mechanism of hypermutation is taken into account to be one of many final nice mysteries in molecular biology. Mutation can result in genomic instability, so how are mutations selectively brought to antibody-encoding genes in activated B cells?
A significant leap forward got here in 2000 with the invention that activation-induced deaminase (AID) is actually required for hypermutation. This used to be in 2002 via facts that relief without delay edits the DNA that encodes an antibody in an activated B mobile. a lot has on account that been learnt in regards to the biochemistry and law of reduction, however the mechanism wherein it truly is recruited in particular to antibody-encoding genes continues to be enigmatic. knowing this recruitment is clinically major simply because off-target reduction job at oncogenes may end up in chromosomal translocations and tumorigenesis.
This e-book summarizes the examine on relief within the context of its relevant position within the affinity maturation of B cells.

Show description

Read Online or Download Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci PDF

Similar molecular biology books

Download e-book for kindle: Cryo-EM, Part C: Analyses, Interpretation, and Case Studies: by Grant Jensen

This quantity, in addition to half A and half B, is devoted to an outline of the tools, samples, protocols, and analyses that belong to cryo-EM. It emphasizes the relatedness of the guidelines, instrumentation, and techniques underlying all cryo-EM ways, which permit practitioners to simply circulation among them.

Nilanjana Maulik Ph.D.,Nilanjana Maulik's Cardiovascular Diseases: Nutritional and Therapeutic PDF

With heart problems ultimate one of many basic motives of morbidity and mortality around the globe, there's a nice have to extra comprehend the molecular foundation of this sickness type and advance new healing or preventative measures. Cardiovascular ailments: dietary and healing Interventions offers updated info at the pathobiology of cardiovascular ailments, emphasizing rising therapeutics and dietary interventions.

Download e-book for iPad: Lipoprotein Metabolism by H. Greten

Symposium on Lipoprotein Metabolism, held in Heidelberg, September 10-13, 1975

Download PDF by Christian Barbato,Francesca Ruberti: Mapping of Nervous System Diseases via MicroRNAs (Frontiers

Lately, realizing of microRNA (miRNA) biogenesis, the molecular mechanisms during which miRNAs control gene expression, and the practical roles of miRNAs has improved. Mapping of worried procedure ailments through MicroRNAs presents an up to date evaluation at the functionality of miRNA in neurological ailments in addition to developments in know-how for healing modulation of miRNA job.

Extra resources for Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci

Sample text

Download PDF sample

Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci by Andrew Franklin

by Brian

Rated 4.31 of 5 – based on 29 votes